May effectively lower prolactin levels in patients w/ pituitary tumors but does not obviate the necessity for RT or surgery. Possible pulmonary infiltrates, pleural effusion & thickening in long-term treatment. Immediately w/draw medication if fibrotic changes in retroperitoneum are diagnosed & suspected. Hypotension. Periodic BP monitoring during the 1st few days of therapy. Immediately discontinue use & promptly evaluate patient if severe progressive or unremitting headache, other CNS toxicity signs or HTN develop. Concomitant use w/ phenothiazines or other medications known to lower BP. Avoid alcohol. Concomitant use w/ other ergot derivatives & any potential vasoconstrictor drug is not recommended. Acromegalic patients w/ history or evidence of peptic ulceration. Possible recurrence in long-term continuous dosage in amenorrhea/galactorrhea. High doses in Parkinson's disease may be associated w/ mental confusion & disturbances. Patients w/ history of MI; residual, atrial, nodal or ventricular arrhythmia. Periodic evaluation of hepatic, hematopoietic, CV & renal function in patients receiving antihypertensive medication. Concomitant use w/ erythromycin; domperidone. Severe renal or hepatic disease. Dizziness may occur; caution against activities requiring rapid & precise responses eg, driving an automobile or operating dangerous machinery. Women of childbearing potential should use a reliable contraception method; conduct pregnancy test at least every 4 wk during amenorrheic period & every time menstrual period is missed once menses are reinitiated. Pregnancy.
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